Profile

541d60b7b3f63adf1e1e8ed4_team_Laurent_L.jpg

Laurent Ruibang Luo, PhD Co-founder & CEO

Dr. Luo is a recognized thought leader in the field of applied bioinformatics. He has played an important role in enabling the translation of “Big Data” to useful biological knowledge, by developing SOAP (Short Oligonucleotide Analysis Package) series open source software widely used today including well acknowledged SOAP3-dp for alignment of short oligonucleotides onto reference sequences and SOAPdenovo2 for de novo large genome assembly, providing full solution to next generation sequencing data analysis. A graduate from the Department of Computer Science, The University of Hong Kong, Dr. Luo has engaged in or organized a number of national projects, including Yan Huang Project, 1000 Genomes Project, Oyster Genome Project, and the Cancer Genome Project, among others. He has more than 20 papers published in high-impact peer reviewed scientific journals, including Nature, Nature Biotechnology, Sciences and Bioinformatics. He is also the project manager of the HKU-BGI Bioinformatics Algorithms and Core Technology Research Laboratory (BAL) and he worked as the director of the Bioinformatics Algorithm Research Laboratory in BGI. His passion is to introduce the latest computational advances into genomics.

Selected Publications

  • COPE: an accurate k-mer-based pair-end reads connection tool to facilitate genome assembly. Bioinformatics, 2012; 28(22):2870-2874
  • Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nature Biotechnology, 2011; 29:723-730
  • Building the sequence map of the human pan-genome. Nature Biotechnology, 2009; 28(1):57-63
  • The oyster genome reveals stress adaptation and complexity of shell formation. Nature, 2012; 490:49-54
  • BALSA: Integrated secondary analysis for whole-genome and whole-exome sequencing, accelerated by GPU. PeerJ, 2(2014):e421
  • SOAPdenovo-Trans: De novo transcriptome assembly with short RNA-Seq reads. Bioinformatics, 2014; 30(12):1660-1666
  • SOAPdenovo2: An empirically improved memory-efficient short-read de novo assembler. BMC GigaScience, 2012; 1:18
  • SOAP3-dp: Fast, Accurate and Sensitive GPU-Based Short Read Aligner. PloS ONE, 8(5):e65632
  • Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude. Science, 2010; 329(5987):75-78
  • International network of cancer genome projects. Nature, 2010; 464(7291):993-998
  • A map of human genome variation from population scale sequencing. Nature, 2010; 467(7319):1061-1073
  • An integrated map of genetic variation from 1,092 human genomes. Nature, 2012; 491:56-65
  • The DNA Methylome of Human Peripheral Blood Mononuclear Cells. PLoS Biology, 2010; 8(11):e1000533
  • Assemblathon 1: A competitive assessment of de novo short read assembly methods. Genome Research, 2011; 21(12);2224-2241
  • Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species. GigaScience, 2013; 2:10