Laurent Ruibang Luo, PhD
Co-founder & CEO
Dr. Luo is a recognized thought leader in the
field of applied bioinformatics. He has played an important role in enabling
the translation of “Big Data” to useful biological knowledge, by developing
SOAP (Short Oligonucleotide Analysis Package) series open source software
widely used today including well acknowledged SOAP3-dp for alignment of short
oligonucleotides onto reference sequences and SOAPdenovo2 for de novo large genome assembly, providing
full solution to next generation sequencing data analysis. A graduate from the Department
of Computer Science, The University of Hong Kong, Dr. Luo has engaged in or
organized a number of national projects, including Yan Huang Project, 1000
Genomes Project, Oyster Genome Project, and the Cancer Genome Project, among
others. He has more than 20 papers published in high-impact peer reviewed
scientific journals, including Nature, Nature Biotechnology, Sciences and
Bioinformatics. He is also the project manager of the HKU-BGI
Bioinformatics Algorithms and Core Technology Research Laboratory (BAL) and he
worked as the director of the Bioinformatics Algorithm Research Laboratory in
BGI. His passion is to introduce the latest computational advances into
genomics.
Selected Publications
- COPE: an accurate k-mer-based pair-end reads connection tool to facilitate genome assembly. Bioinformatics, 2012; 28(22):2870-2874
- Structural variation
in two human genomes mapped at single-nucleotide resolution by whole genome de
novo assembly. Nature Biotechnology,
2011; 29:723-730
- Building the sequence map of the human
pan-genome. Nature Biotechnology, 2009; 28(1):57-63
- The oyster
genome reveals stress adaptation and complexity of shell formation. Nature,
2012; 490:49-54
- BALSA: Integrated secondary analysis for
whole-genome and whole-exome sequencing, accelerated by GPU. PeerJ,
2(2014):e421
- SOAPdenovo-Trans: De novo transcriptome assembly
with short RNA-Seq reads. Bioinformatics, 2014; 30(12):1660-1666
- SOAPdenovo2: An
empirically improved memory-efficient short-read de novo assembler. BMC
GigaScience, 2012; 1:18
- SOAP3-dp: Fast,
Accurate and Sensitive GPU-Based Short Read Aligner. PloS ONE, 8(5):e65632
- Sequencing of
50 Human Exomes Reveals Adaptation to High Altitude. Science,
2010; 329(5987):75-78
- International network of cancer
genome projects. Nature, 2010;
464(7291):993-998
- A map of human
genome variation from population scale sequencing. Nature,
2010; 467(7319):1061-1073
- An integrated map of genetic variation from
1,092 human genomes. Nature, 2012;
491:56-65
- The DNA Methylome of Human
Peripheral Blood Mononuclear Cells. PLoS Biology, 2010; 8(11):e1000533
- Assemblathon 1: A competitive assessment of de novo short read assembly
methods. Genome Research, 2011;
21(12);2224-2241
- Assemblathon 2: evaluating de novo methods of
genome assembly in three vertebrate species. GigaScience, 2013; 2:10
